Extracellular Matrices, Uses thereof, and Method for Making Extracellular Matrices

A method of making an EMR-drug conjugate comprising:

• (a) reacting a small molecule of formula (XVIII) with a compound of formula (XIXa) or formula (XIXb) to yield a compound of formula (XXa) or (XXb):
• wherein Q3 is a residue of a small molecule, and
• wherein d is 0 or an integer between 1 and 500, between 1 and 250, between 1 and 200, between 1 and 100, between 1 and 50, or between 1 and 10;
• (b) reacting the compound of formula XXa or formula XXb with a dextran of formula X:
• wherein R4 is H, allyl carbamate, or mixtures thereof;
• (c) optionally adding to the product of step (b) an acrylate-comprising compound selected from the group consisting of polyethylene(glycol)diacrylate, polyethylene(glycol)acrylate, acrylate-polyethylene(glycol)-succinimidyl valeric acid, and mixtures thereof;
• and
• (d) curing the product of step (b) or step (c) with UV light and/or visible light.