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US 2021/0069233 A1Published application
Blockade of miR466l-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease
AssigneeYale University
InventorsJeffrey Bender, Vinod Ramgolam, Timur Yarovinsky
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Abstract
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of inflammatory disease, in particular, multiple sclerosis.
Claims8
A composition comprising a polyribonucleic acid comprising the sequence ATAAATA and at least one modification selected from the group consisting of locked nucleic acid, bridged nucleic acid, phosphorothioate nucleic acid and peptide nucleic acid.
Dependencies are inferred from the claim text.