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US 2021/0069205 A1Published application
Bace1 inhibition for the treatment of cancer
AssigneeThe Cleveland Clinic Foundation
InventorsShideng Bao, Kui Zhai
Life of this patent
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Abstract
Provided herein are compositions, systems, kits, and methods for treating a subject with cancer by administering a BACE1 inhibitor, such as MK-8931. In particular embodiments, the subject is treated with radiation (e.g., low dose radiation) first, and then administered a BACE1 inhibitor within a certain time window (e.g., about 3 hours to 6 days after the radiation treatment).
Claims20
A method of treating a subject with cancer comprising:
- a) treating a subject having cancer with radiation, and
- b) administering a BACE1 inhibitor to said subject.
A method of treating a subject with cancer comprising:
- administering a BACE1 inhibitor from Table 1 to said subject, wherein said subject has cancer.
Dependencies are inferred from the claim text.