Use of neutrophil elastase inhibitors in liver disease
AssigneepH Pharma Co., Ltd.
InventorsSanjeev SATYAL, Brian ROBERTS, Xueyan WANG, Scott SAVAGE, Hoyoung HUH
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Abstract
The invention relates to methods for treating chronic liver disease, in particular nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), with neutrophil elastase inhibitors. The invention further relates to pharmaceutical compositions comprising neutrophil elastase inhibitors.
Claims19
A method of treating chronic liver disease, comprising administering a therapeutically effective amount of (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile or a pharmaceutically acceptable salt, polymorph, solvate, or solvates of the salts thereof to a patient in need of treatment.
A pharmaceutical composition for the treatment of chronic liver disease comprising (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile or a pharmaceutically acceptable salt, polymorph, solvate, or solvates of the salts thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.