Synergistic pharmaceutical combination of the active enantiomer s-ketorolac tromethamine and tramadol chlorhydrate
AssigneesFederico Amezcua Amezcua, Carlos Amezcua Amezcua
InventorPatricia del Carmen Garcia Armenta
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Abstract
The present invention relates to a pharmaceutical composition comprising the synergistic combination of a non-steroidal anti-inflammatory drug (NSAID), such as the active ingredient s-ketorolac tromethamine, and an opioid agent, such as the active ingredient tramadol chlorhydrate, which ingredients are formulated with pharmaceutically acceptable excipients. The composition is used for the control and treatment of mild and/or moderate and/or severe pain.
Claims13
A pharmaceutical synergistic combination, characterized in that it comprises:
- i. an NSAID agent and/or pharmaceutically accepted salts thereof,
- ii. an opioid agent and/or pharmaceutically accepted salts thereof,
- iii. a vehicle and/or pharmaceutically accepted excipient,
- the combination having been demonstrated in a preclinical trial for oral administration and being indicated for the control and treatment of neuropathic and/or nociceptive pain diseases in mammals.
A treatment method for neuropathic and/or nociceptive pain which comprises the administration to mammals suffering from neuropathic and/or nociceptive pain of an effective amount of a combination of at least one NSAID and at least one opioid.
Dependencies are inferred from the claim text.