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AssigneeTechno Guard Co., Ltd.
InventorKiichiro NABETA
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An object of the present invention is to provide a non-aqueous composition having a drug carried therein, the composition being capable of preparing a drug-containing fat emulsion that is usable as an injection, an eye drop, a nasal drop, an inhalant, or the like by being mixed with an aqueous medium in use without producing a drug-containing fat emulsion in advance, and a method for producing the non-aqueous composition. The non-aqueous composition having a drug carried therein of the present invention as a resolution for achieving the object is characterized by comprising an oil or fat, a slightly water soluble drug, and an emulsifier which are dissolved in a polyhydric alcohol as a water soluble carrier at a content of the oil or fat of 0.05 to 250 mg/g, a weight ratio of the slightly water soluble drug to the oil or fat (slightly water soluble drug/(oil or fat)) of 0.0001 to 50 (provided that the total content of the slightly water soluble drug and the oil or fat is at most 300 mg/g), and a content of the emulsifier of 20 to 500 mg/g.
A non-aqueous composition having a drug carried therein, characterized by comprising an oil or fat, a slightly water soluble drug, and an emulsifier which are dissolved in a polyhydric alcohol as a water soluble carrier at a content of the oil or fat of 0.05 to 250 mg/g, a weight ratio of the slightly water soluble drug to the oil or fat (slightly water soluble drug/(oil or fat)) of 0.0001 to 50 (provided that the total content of the slightly water soluble drug and the or fat is at most 300 mg/g), and a content of the emulsifier of 20 to 500 mg/g.
A method for producing a nonaqueous composition having a drug carried therein, characterized by comprising dissolving an oil or fat, a slightly water soluble drug, and an emulsifier in a polyhydric alcohol as a water soluble carrier at a content of the oil or fat of 0.05 to 250 mg/g, a weight ratio of the slightly water soluble drug to the oil or fat (slightly water soluble drug/(oil or fat)) of 0.0001 to 50 (provided that the total content of the slightly water soluble drug and the oil or fat is at most 300 mg/g), a content of the emulsifier of 20 to 500 mg/g.
Dependencies are inferred from the claim text.