Oral cannabinoid compositions and methods for treating neuropathic pain
AssigneeAvicanna Inc.
InventorsFrantz Henri Emmanuel LE DEVEDEC, Aras Azadian, Setu Nimish Purohit, Justin Michael Grant, Samantha Carolyn Watt
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Abstract
Self-emulsifying drug delivery systems are provided for oral delivery of cannabinoids. The cannabinoids are dissolved in an oily medium (e.g. medium chain triglycerides) together with at least one surfactant to improve dissolution, stability, and bioavailability. Also provided are methods comprising uses of an oral cannabinoid compositions for the treatment of neuropathic pain in a subject.
Claims15
A self-emulsifying oral composition comprising a cannabinoid at 0.01-10% (w/w), a surfactant at 40-50% (w/w), an oil or semi-solid fat at 15-25% (w/w), and a co-solvent at 25-35% (w/w), wherein the said composition forms in-situ oil-in-water emulsion upon contact with aqueous media such as gastrointestinal fluids.
The oral cannabinoid composition of 1, wherein the composition has in-vivo peak plasma levels in the range of 900 to 1100 ng/ml at 1 hour.
Dependencies are inferred from the claim text.