Biofilm penetrating compositions and methods

A method of treating a surface or product to kill or inhibit planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm, the biofilm comprised of at least a matrix and bacteria or fungi, the method comprising:

• providing a composition having an active ingredient comprising:
• a combination of an effective amount of a salt having a cation Nα C8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester and an anion selected from the group consisting:
• of halide, nitrite, nitrate, linoleate, linolenate, laurate, oleoate, phenolate, polyphenolate, carboxylate, hydroxycarboxylate, hyaluronate, antibiotic anion, resveratrol, and an amino acid, the salt being present in an amount from about 0.0012 wt % to about 10 wt % and
• an effective amount of a sugar ester of a fatty acid being present in an amount from about 0.0200 wt % to about 30 wt %, and
• the composition optionally comprising one or more of:
• a solvent being present in an amount from about 5 wt % to about 99.9 wt %;
• or
• a thickener or carrier or gelling agent being present in an amount from about 1.0 wt % to about 10.0 wt %;
• or
• an esterase inhibitor being present in an amount from about 0.05 wt % to about 5 wt %;
• or
• a hydrogel having a three-dimensional hydrophilic polymer network,
• applying the composition to a surface or product to kill or inhibit planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm on the surface or product,
• wherein the active ingredient of the composition kills or inhibits planktonic bacteria or fungi and penetrates the biofilm matrix and kills or inhibits biofilm bacteria or fungi.

A composition having an active ingredient comprising:

• a combination of an effective amount of a salt having a cation Nα C8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester and an anion selected from the group consisting:
• of halide, nitrite, nitrate, linoleate, linolenate, laurate, oleoate, phenolate, polyphenolate, carboxylate, hydroxycarboxylate, hyaluronate, antibiotic anion, resveratrol, and an amino acid, the salt being present in an amount from about 0.0012 wt % to about 10 wt % and
• an effective amount of a sugar ester of a fatty acid being present in an amount from about 0.020 wt % to about 30 wt %, and
• the composition optionally comprising one or more of:
• a solvent being present in an amount from about 5 wt % to about 99.9 wt %;
• or
• a thickener or carrier or gelling agent being present in an amount from about 1.0 wt % to about 10.0 wt %;
• or
• an esterase inhibitor being present in an amount from about 0.05 wt % to
• about 5 wt %;
• or a hydrogel having a three-dimensional hydrophilic polymer network.