Detection of an autoantibody
AssigneeEUROIMMUN Medizinische Labordiagnostika AG
InventorsSusanne SCHOCH MCGOVERN, Albert Becker
Life of this patent
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Abstract
A diagnostically useful carrier includes a peptide including the amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a variant thereof. A kit, a composition, a detection method, use for detecting a neurological disease, a human autoantibody specifically binding to Drebrin and a therapeutic compound or combination for use in the treatment of a neurological use are also useful.
Claims16
A diagnostically useful carrier, comprising:
- a peptide comprising
- the amino acid sequence set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or a variant thereof.
A method for diagnosing a neurological disease, comprising:
- detecting in a sample of a patient the presence of an autoantibody specifically binding to Drebrin.
A composition, comprising:
- a) a peptide comprising
- the amino acid sequence set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, or a variant thereof, and
- b) a pharmaceutically acceptable carrier.
A method of detecting the presence or absence of an autoantibody specifically binding to Drebrin, the method comprising:
- i) contacting a sample isolated from a subject having a neurological disease with a peptide comprising
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or a variant thereof,
- wherein the peptide binds specifically to autoantibodies binding to SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or the variant thereof;
- and
- ii) detecting the presence or absence of the autoantibody against Drebrin in a complex with the peptide.
A method, comprising:
- manufacturing a kit for detecting a neurological disease with
- (i) a peptide comprising
- the amino acid sequence set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or a variant thereof, or
- (ii) a nucleic acid vector encoding a peptide comprising
- the amino acid sequence set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or the variant thereof.
A patient sample or a purified derivative of said sample, comprising:
- an autoantibody specifically binding to Drebrin,
- wherein the patient sample or the purified derivative is a positive control in an immunoassay.
A therapeutic compound or a combination of therapeutic compounds for use in the treatment of a neurological autoimmune disease,
- wherein the neurological autoimmune disease is associated with autoantibodies specifically binding to Drebrin, and
- wherein the therapeutic compound or the combination is selected from the group consisting of
- a) valproate, lamotrigine, levetiracetam, lacosamide, oxcarbazepine, clobazam, and zonisamide;
- and/or
- b) an immunosuppressant and a peptide comprising the amino acid sequence set forth in SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, or a variant thereof.
Dependencies are inferred from the claim text.