Apparatus and methods for detection of diabetes-associated molecules using electrochemical impedance spectroscopy
AssigneesArizona Board of Regents on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
InventorsJeffrey LaBelle, Chi Lin, David Probst, Koji Sode, Curtiss Cook
Life of this patent
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Abstract
Methods and apparatus for detecting binding of a diabetes-related target molecule analyte in a sample utilizing Electrochemical Impedance Spectroscopy (EIS). Sensor electrodes include a diabetes-related target-capturing molecule immobilized thereto, and an EIS-based imaginary impedance measurement is utilized to arrive at a concentration of the analyte.
Claims29
An apparatus for detecting one or more diabetes-related analytes in a bodily fluid sample utilizing Electrochemical Impedance Spectroscopy (EIS), comprising:
- an electrochemical sensor operably configured to provide an electrochemical impedance measurement of a diabetes-related analyte in the fluid, the sensor including a diabetes-related target-capturing molecule immobilized to a working electrode.
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An apparatus for detecting insulin in a bodily fluid sample utilizing Electrochemical Impedance Spectroscopy (EIS), comprising:
- an electrochemical sensor operably configured to provide an electrochemical impedance measurement of insulin in the fluid, the sensor including an insulin-capturing molecule immobilized to a working electrode.
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A method for detecting binding of a diabetes-related target molecule analyte in a sample utilizing Electrochemical Impedance Spectroscopy (EIS), comprising:
- contacting an electrode with the sample, wherein the electrode includes a diabetes-related target-capturing molecule immobilized thereto, and wherein the electrode is operably configured to provide an EIS-based imaginary impedance measurement of the sample;
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- detecting the binding of the diabetes-related target molecule analyte in the sample to the target-capturing molecule by detecting a change in an imaginary impedance measurement.
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Dependencies are inferred from the claim text.