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US 2021/0061879 A1Published application
Meditope-enabled t cells
AssigneeCity of Hope
InventorsJohn C. WILLIAMS, Christine BROWN, Kurt JENKINS, Yi-Chiu KUO, Cheng-Fu KUO
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Abstract
Provided herein are compositions which exhibit novel therapeutic capabilities and allow to reduce the off-target effect of therapeutic antibodies. The compositions include recombinant proteins that if expressed by a T cell can efficiently recruit therapeutic antibodies to their site of action.
Claims57
A recombinant protein comprising:
- a non-CDR Fab binding peptide domain;
- (ii) an intracellular T-cell signaling domain;
- and
- (iii) a transmembrane domain connecting said non-CDR Fab binding peptide domain to said intracellular T-cell signaling domain.
1 more element
Dependencies are inferred from the claim text.