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US 2021/0061847 A1Published application
Aqueous suspension compositions, formulations, and water dispersible dry compositions comprising 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-ketone and hydrates, derivatives, and analogs thereof
AssigneeSD Chem, Inc.
InventorYu GE
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Abstract
Composition comprising a stable aqueous suspension formulation, which may be reconstituted from a water dispersible dry composition, comprising compound of Formula I in the form of particles stabilized in an aqueous suspension. It causes little or no injection site irritation and has superior properties over non-aqueous formulations. It stimulates autophagy, enhance innate immunity, down-regulates unproductive inflammation and exerts a Th1 immune bias. It demonstrates better efficacy in both in vitro and in vivo models.
Claims20
A composition, comprising
- at least 30% w/w water based on total weight of the composition, and
- a compound of Formula I:
- wherein n is 0 to 4;
- the solvate is H2O, C1-4—OH, C1-4—OH, C1-4—COOH, C1-4—COOC1-4 tetrahydrofuran, 1,4-dioxane, (CH3)2O, (C2H5)2O, HC(O)N(CH3)2, (CH3)2SO, or a combination thereof;
- X is F, Cl, Br, or I;
- R is a protecting group,
- wherein the compound is in form of particles stabilized as an aqueous suspension in the water.
4 more elements
Dependencies are inferred from the claim text.