Aav/xbp1s-ha virus, gene therapy method and use thereof in the optimisation and improvement of learning, memory and cognitive capacities
AssigneeUniversidad De Chile
InventorsClaudio Andres HETZ FLORES, Gabriela Raquel Elena MARTINEZ BRAVO
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Abstract
This invention presents a sequence of the virus AAV/XBP1s-HA, method and its use in the improvement of cognitive functions, of memory and of learning, as presented in the in vivo studies in FIG. 12/17 right panel.
Claims20
A method of treating a disease related to the memory, cognitive or learning capacity in a mammal subject in need thereof, said method comprising administering a therapeutically efficient amount of a viral vector that induces neuronal overexpression of XBP1 in the brain, wherein said viral vector comprises an expression cassette with a nucleotide sequence encoding the neuronal transcription factor XBP1.
A method for optimizing memory or cognitive processes in a mammal in need thereof comprising administering to the mammal a pharmaceutical composition comprising an adeno-associated vector (AAV) and a pharmaceutically acceptable excipient, wherein said AAV comprises a recombinant viral genome and an expression cassette with a regulating region operatively linked to a polynucleotide that encodes a protein comprising X-box protein 1 (XBP1).
An AAV vector comprising a recombinant genome with an expression cassette that induces neuronal overexpression of XBP1 in the brain of a mammal, wherein said neuronal overexpression of XBP1 improves the performance of the memory, cognitive or learning capacities in said mammal.
Dependencies are inferred from the claim text.