Lipid nanoparticle compositions and methods for mrna delivery
AssigneeTranslate Bio, Inc.
InventorsBraydon Charles Guild, Frank DeRosa, Michael Heartlein
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Abstract
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.
Claims24
1-40. (canceled)
A method for delivery of messenger RNA (mRNA) for in vivo production of a IL-12 polypeptide, comprising administering, to a human, a composition comprising an mRNA that encodes the IL-12 polypeptide wherein the mRNA is encapsulated within a lipid nanoparticle, wherein the administering of the composition results in expression of the IL-12 polypeptide encoded by the mRNA that is detectable in a target tissue or in serum at least 72 hours after administration, and wherein the lipid nanoparticle comprises one or more PEG-modified lipids.
Dependencies are inferred from the claim text.