Back to results
US 2021/0060129 A1Published application
Igg4 fc fragment comprising modified hinge region
AssigneeHanmi Pharm. Co., Ltd.
InventorsSung Youb JUNG, Yong Ho Huh, Sung Hee Park, Jong Soo Lee, In Young Choi
Life of this patent
Estimating the term…
Abstract
A modified IgG4 Fc fragment useful as a drug carrier is disclosed. When coupled to a drug, the resulting drug-IgG4 Fc conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
Claims9
1-21. (canceled)
A drug conjugate comprising a modified aglycosylated IgG4 Fc fragment and a drug,
- wherein the drug is conjugated to the modified aglycosylated IgG4 Fc fragment via a linker, and
- wherein the modified aglycosylated IgG4 Fc fragment consists of the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.