Oxytocin compositions for treatment of tinnitus
AssigneeNew York University
InventorsLawrence C. Newman, James Cramer
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Abstract
Provided are methods and compositions for treatment of tinnitus. The method comprises administration of therapeutically effective amount of oxytocin, which may be present with a thickener, and may be delivered to the back of the nasal cavity in a suitable form. Compositions of oxytocin for intranasal delivery and sprayable unit compositions of oxytocin are also provided.
Claims20
A method of treating tinnitus comprising administering intranasally to an individual in need of treatment from 50 to 260 IU of oxytocin over a 24 hour period.
A method of treating tinnitus in an individual comprising delivering to the upper nasal cavity of the individual oxytocin in a powdered or aerosolized form, wherein the oxytocin is delivered in a powdered form at an amount of about 20 to 225 IU of oxytocin over a 24 hour period.
A pharmaceutical composition for intranasal administration comprising about 100 to 600 IU of oxytocin per ml, and a thickener present in an amount of from 5% to 12% by weight of the composition, said thickener having a viscosity of from about 4,000 to 12,000 cps.
A sprayable unit dose of oxytocin formulated for intranasal administration comprising from 15 to 65 IU of oxytocin and a thickener present in an amount of from about 5% to 12% by weight of the composition, said thickener having a viscosity of from about 4,000 to 12,000 cps.
Dependencies are inferred from the claim text.