US 2021/0060053 A1Published application

Development of polylysine:epigallocatechin-3-o-gallate and dsrna polyplexes for control of mosquitoes

AssigneeUniversity of Kentucky Research Foundation

InventorsSubba Reddy Palli, Ramesh Dhandapani

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Abstract

The present invention relates to a polyplex composition for modulating expression of a gene-of-interest in an insect comprising: a crosslinker, a cation, and a molecule for initiating RNA interference (RNAi). The present invention further relates to polyplex compositions for modulating genes of interest in Aedes aegypti. The present invention further relates to methods of modulating a gene-of-interest in an insect, comprising: administering to an insect a polyplex composition for modulating expression of a gene-of-interest in an insect comprising: a crosslinker, a cation, and a molecule for initiating RNA interference (RNAi).

Claims20

Dependent claims

A polyplex composition, comprising:

a cation;
a crosslinker;
and a molecule for initiating RNAi;
wherein the cation:crosslinker ratio is from about 1:0.1 to about 1:100.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 17/006,588Filed 28 Aug 2020
Priority: 28 Aug 2019
Published: 4 Mar 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
A61K 47/32
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained by reactions only involving…
A61K 47/545
The modifying agent being an organic compound: heterocyclic compounds
A61K 47/59
The modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule: obtained otherwise than by…

Family

Application62/893,012Us provisional application · filed 28 Aug 2019
US 11,793,829 B2Related patent
US 2021/0060053 A1This patent

From the US filing history. Foreign family members aren’t listed.

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