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US 2021/0002292 A1Published application
Modulators of the nmda receptor
AssigneeH. Lundbeck A/S
InventorsJohn Paul Kilburn, Erhad Ascic, Mauro Marigo, Laurent David
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorders or neuropsychiatric disorders such as depression.
Claims24
A compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of a hydrogen, halogen, C1-4 haloalkyl, cyano, C3-6 cycloalkyl, and C1-4 alkyl;
- R2 is selected from the group consisting of hydrogen, halogen, C1-4 haloalkyl, cyano, C3-6 cycloalkyl, and C1-4 alkyl;
- R3 is selected from the group consisting of hydrogen, halogen, C1-4 haloalkyl, cyano, C3-6 cycloalkyl, and C1-4 alkyl;
- R4 is selected from the group consisting of hydrogen, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 hydroxyhaloalkyl, cyano, NRaRb, SRcRd, OR6, L-(OR6), and R7;
- Ra and Rb are independently selected from the group consisting of hydrogen and C1-4 alkyl;
- Rc and Rd are independently selected from the group consisting of hydrogen and C1-4 alkyl;
- R6 is selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, and C1-4 hydroxyhaloalkyl;
- L represents a C1-3 alkylene;
- and
- R7 is selected from the group consisting of C3-6 cycloalkyl, phenyl, 4, 5, or 6 membered heterocycle, and 5 or 6 membered heteroaryl, wherein said cycloalkyl, phenyl, heterocycle or heteroaryl are independently unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, C1-3 alkyl, C1-3 alkoxy, wherein said C1-3 alkyl and C1-3 alkoxy are independently unsubstituted or substituted with 1, 2 or 3 F.
7 more elements
20-22. (canceled)
26-27. (canceled)
Dependencies are inferred from the claim text.