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AssigneeCedars-Sinai Medical Center
InventorCHRISTOPHER WHEELER
Estimating the term…
Methods and systems for diagnosing, providing prophylaxis, and treating one or more age-related neurodegeneration or pathological cognitive impairment are provided. An increased presence of CD103+ resident memory CD8+ T cells (CD8+ TRM) can be detected in blood sample obtained from the human subjects with one or more symptoms of loss of short-term or long-term memory, decreased ability to maintain focus, and decreased problem-solving capacity. An increased presence of CD103+ CD8+ TRM can be compared to a value obtained from one or a pool of healthy human subjects with none of the one or more symptoms. One or more of a therapeutically effective amount of: an inhibitor of cluster of differentiation (CD103), an inhibitor of perforin-1, and an inhibitor of interferon gamma (IFNγ) can be administered as treatment of age-related neurodegeneration or pathological cognitive impairment. Pathological neurodegeneration can include Parkinson's disease, multiple sclerosis, or Alzheimer' s disease.
A method for treating, inhibiting, reducing the severity of or promoting prophylaxis of age-related cognitive decline, mild cognitive impairment, pathological neurodegeneration, or a combination thereof, in a subject in need thereof, comprising:
A method of treating, inhibiting, reducing the severity or promoting prophylaxis of age-related cognitive decline or of pathological neurodegeneration comprising at least one of multiple sclerosis, Parkinson's disease or Alzheimer's disease in a subject in need thereof, comprising:
A method of identifying a human subject susceptible to or experiencing an age-related cognitive decline or a pathological neurodegeneration, comprising detecting an increased presence of CD103+ resident memory CD8+ T cells (CD8+ TRM) in a blood sample obtained from the human subject with one or more symptoms of loss of short-term or long-term memory, decreased ability to maintain focus, and decreased problem solving capacity.
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