Articles and methods directed to personalized therapy of cancer
AssigneesOPKO Pharmaceuticals, LLC, The Scripps Research Institute, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, PJSC Pharmsynthez, Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Alexander Gabibovich Gabibov
InventorsAlexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
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Abstract
Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
Claims25
A method of treating cancer in a subject comprising concomitantly administering:
- CAR-expressing T-cells, wherein the CAR comprises an antigen binding domain that specifically binds a cancer-specific antigen in a cancer-specific manner;
- and
- a vaccine comprising a polypeptide or a nucleic acid expressing the cancer-specific antigen, or a cancer-specific fragment thereof.
Dependencies are inferred from the claim text.