Reagents and Methods for Breast Cancer Detection
OwnerKristi EGLAND, Rick EVANS +1inventors
InventorsKristi EGLAND, Rick EVANS, James POTTALA
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Abstract
The present invention provides compositions including reagents for detecting human autoantibodies against at least two proteins selected from the group consisting of ANGTPL4, DKK1, EPHA2, LAMC2, SPON2, SSR2, GAL1, GFRA1, LRRC15, CD147, CD320, CDH3, LRP10, SPINT2, SUSD2, and CST2, and their use in detecting breast cancer or disease recurrence.
Claims13
A method for detecting breast cancer or disease recurrence, comprising (a) contacting a bodily fluid sample from a subject at risk of having breast cancer or breast cancer recurrence with one or more proteins selected from the group consisting of ANGTPL4, DKK1, EPHA2, LAMC2, SPON2, SSR2, GAL1, GFRA1, LRRC15, CD147, CD320, CDH3, LRP10, SPINT2, SUSD2, and CST2, secreted versions thereof, or extracellular domains thereof;
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- (b) detecting binding of autoantibodies in the bodily fluid sample against the one or more proteins, secreted versions thereof, or extracellular domains thereof;
- wherein the presence of autoantibodies against the one or more proteins, secreted versions thereof, or extracellular domains thereof correlates with a likelihood of the subject having breast cancer or breast cancer recurrence.
Dependencies are inferred from the claim text.