Particle assemblies, methods of making and use
AssigneesStemcell Technologies Canada Inc., The University of British Columbia
InventorsRuss Algar, Michael Van Tran
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Abstract
The present application is directed to a composite material comprising a core that is responsive to a magnet or a magnetic field, surrounded by a polymer that has been chemically modified to spontaneously bind and assemble a dense corona of fluorescent quantum dots, which is then over-coated with another layer of modified polymer that can be bound by an antibody complex for targeting specific antigens. Methods of preparing and using this material for the detection and quantification of target antigens is also included in the application.
Claims27
A particle assembly comprising:
- a. a core that is responsive to a magnetic field;
- b. a first polymer coating surrounding the core the first polymer being chemically modified to bind quantum dots;
- c. a second polymer over-coating external to the first polymer coating, the second polymer being chemically modified to bind the quantum dots;
- and
- d. quantum dots bound to the first polymer coating and the second polymer coating.
Dependencies are inferred from the claim text.