Nanopore Sensing With a Fluidic Passage

A method for sensing translocation of a molecule through a nanopore comprising:

• directing to an inlet of the nanopore at least one molecule in a first fluidic solution in a first fluidic reservoir, said first fluidic reservoir being disposed in direct fluidic connection with the inlet of the nanopore;
• translocating the molecule in the first fluidic solution through the nanopore to a nanopore outlet and through a fluidic passage disposed in direct fluidic connection with the nanopore outlet, to a second fluidic solution in a second fluidic reservoir disposed in direct fluidic connection with the fluidic passage, said fluidic passage having at least one fluidic section with a fluidic section length greater than a fluidic section width;
• and
• measuring an electrical potential local to the fluidic passage during translocation of the molecule to sense translocation of the molecule.