Cancer-related biological materials in microvesicles
AssigneeThe General Hospital Corporation
InventorsJohan Karl Olov SKOG, Leonora BALAJ, Mikkel NOERHOLM, Xandra BREAKEFIELD
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Abstract
Disclosed herein are methods for assaying a biological sample from a subject by analyzing components of microvesicle fractions in aid of risk, diagnosis, prognosis or monitoring of, or directing treatment of the subject for, a disease or other medical condition in the subject. Also disclosed are methods of treatment and identifying biomarkers using a microvesicle fraction of a subject. Kits, pharmaceutical compositions, and profiles related to the methods are also disclosed.
Claims1
A method for assaying a biological sample from a subject in aid of diagnosis, prognosis or monitoring of a disease or other medical condition in the subject, comprising the steps of:
- a. obtaining or using a microvesicle fraction from a biological sample from a subject;
- b. extracting nucleic acid from the fraction;
- and
- c. detecting the presence or absence of a biomarker in the extracted nucleic acid;
- wherein the biomarker is a genetic aberration associated with diagnosis, prognosis, status or stage of a disease or other medical condition, and wherein the genetic aberration is in or corresponds to:
- i. a c-myc gene;
- ii. a transposable element;
- iii. a retrotransposon element;
- iv. a satellite correlated gene;
- v. a repeated DNA element;
- vi. non-coding RNA other than miRNA;
- or
- vii. a fragment of any of the foregoing.
Dependencies are inferred from the claim text.