Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (ra)

A method of treating an individual having RA, the individual being identified as having (i) an increased expression level of one or more genes set forth in Table 2 in a sample from the individual and/or (ii) a decreased expression level of one or more genes set forth in Table 3 in a sample from the individual relative to a reference expression level, the method comprising administering to the individual a therapeutic agent other than, or in addition to, a DMARD.

A method of treating an individual having RA, the method comprising:

• (a) determining an expression level of one or more genes set forth in Table 2 or Table 3 in a sample from the individual, wherein (i) the expression level of one or more genes set forth in Table 2 in the sample is determined to be increased and/or (ii) the expression level of one or more genes set forth in Table 3 is determined to be decreased relative to a reference expression level;
• and
• (b) administering to the individual a therapeutic agent other than, or in addition to, a DMARD based on the expression level of the one or more genes set forth in Table 2 or Table 3 determined in step (a).

A method of identifying an individual having RA who may benefit from a treatment comprising a DMARD, the method comprising determining a myeloid eigengene score from a sample from the individual, wherein a myeloid eigengene score from the sample that is at or above a reference myeloid eigengene score identifies the individual as one who may benefit from a treatment comprising a DMARD.

A method for selecting a therapy for an individual having RA, the method comprising determining a myeloid eigengene score from a sample from the individual, wherein a myeloid eigengene score from the sample that is at or above a reference myeloid eigengene score identifies the individual as one who may benefit from a treatment comprising a DMARD.

A method of treating RA in an individual identified as having a myeloid eigengene score from a sample from the individual that is at or above a reference myeloid eigengene score, the method comprising administering to the individual a DMARD.

A method of treating an individual having RA, the method comprising:

• (a) determining a myeloid eigengene score from a sample from the individual, wherein the myeloid eigengene score from the sample is determined to be at or above a reference myeloid eigengene score;
• and
• (b) administering to the individual a DMARD based on the myeloid eigengene score determined in step (a).