Assessing and treating functional gastrointestinal disorders
AssigneeMayo Foundation for Medical Education and Research
InventorPurna C. Kashyap
Life of this patent
Estimating the term…
Abstract
This document relates to methods and materials involved in assessing and/or treating a mammal having a functional gastrointestinal disorder (FGID) such as irritable bowel syndrome (IBS). For example, methods and materials provided herein can be used for determining if a mammal having a FGID is likely to respond to a particular FGID treatment. This document also provides methods and materials for treating a mammal having a FGID.
Claims22
A method for treating a mammal having a functional gastrointestinal disorder (FGID), wherein said method comprises:
- identifying said mammal as having a small intestinal microbiome comprising two or more microbes selected from the group consisting of Anaeroglobus species, Erwinia species, Escherichia species, Staphylococcus species, Scardovia species, Bifidobacterium species, Lactobacillus species, Olsenella species, Slackia species, and Shuttleworthia species;
- and
- administering an antibiotic to said mammal.
A method for treating a FGID, wherein said method comprises administering an antibiotic to a mammal that has said FGID and that was identified as having a small intestinal microbiome comprising two or more microbes selected from the group consisting of Anaeroglobus species, Erwinia species, Escherichia species, Staphylococcus species, Scardovia species, Bifidobacterium species, Lactobacillus species, Olsenella species, Slackia species, and Shuttleworthia species.
A method for treating a mammal having a FGID, wherein said method comprises:
- identifying said mammal as having a small intestinal microbiome comprising two or more microbes selected from the group consisting of Anaeroglobus species, Erwinia species, Escherichia species, Staphylococcus species, Scardovia species, Bifidobacterium species, Lactobacillus species, Olsenella species, Slackia species, and Shuttleworthia species;
- and comprising a reduced level of two or more microbes selected from the group consisting of Lachnoanaerobaculum species, Prevotella species, Leptotrichia species, Catonella species, Gemella species, Neisseria species, Haemophilus species, and Streptococcus species;
- and
- administering a probiotic to said mammal.
A method for treating a FGID, wherein said method comprises administering an antibiotic to a mammal that has said FGID and that was identified as having a small intestinal microbiome comprising two or more microbes selected from the group consisting of Anaeroglobus species, Erwinia species, Escherichia species, Staphylococcus species, Scardovia species, Bifidobacterium species, Lactobacillus species, Olsenella species, Slackia species, and Shuttleworthia species;
- and comprising a reduced level of two or more microbes selected from the group consisting of Lachnoanaerobaculum species, Prevotella species, Leptotrichia species, Catonella species, Gemella species, Neisseria species, Haemophilus species, and Streptococcus species.
Dependencies are inferred from the claim text.