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US 2020/0399666 A1Published application
Method for preparation of diester derivatives of malonic acid
AssigneeLygos, Inc.
InventorsJeffrey A. Dietrich, Eric Steen, Johan van Walsem
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Abstract
Methods for the preparation of bio-based malonic acid and diester derivatives of malonic acid are provided. The disclosed methods produce diester derivatives of malonic acid with fewer impurities, which is useful for many industrial processes. The diester derivatives of malonic acid can be purified from existing sources of malonic acid, or from malonic acid made from a renewable carbon source.
Claims22
A method for isolating diester derivatives of malonic acid from fermentation broth, comprising:
- separating calcium malonate crystals of at least 10 microns in diameter from the fermentation broth by centrifugation;
- dissolving malonic acid from the calcium malonate crystals in a gypsum reactive crystallizer;
- recrystallizing the dissolved malonic acid in a malonic acid crystallizer;
- refluxing the crystalline malonic acid with a dialkyl carbonate and sulfuric acid to generate diester derivatives of the malonic acid;
- and
- isolating the diester derivatives of malonic acid via distillation.
3 more elements
Dependencies are inferred from the claim text.