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US 2020/0399660 A1Published application
Modified polyamine polymers for delivery of biomolecules into cells
OwnerWenhui Zhou, Trish Hoang +7inventors
InventorsWenhui Zhou, Trish Hoang, Christopher Todd Eggers, Hui Wang, Thomas Machleidt, Brock Binkowski, Poncho Meisenheimer, Frank Fan, Keith Wood
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Abstract
Provided herein are compounds, compositions, and methods for delivering biomolecules to cells. In particular, the present disclosure provides modified polyamine polymers, including polyamine polymers having fluorinated substituents.
Claims31
A compound or a salt thereof, the compound comprising:
- a polyethyleneimine polymer;
- and
- a plurality of substituents bound to amino groups of the polyethyleneimine polymer, wherein each substituent independently has a formula (I):
- —X—(CH2)n—Z (I),
- wherein:
- X is a bond or —C(O)—O—;
- n is 0, 1, 2, 3, 4, or 5;
- and
- Z is selected from a haloalkyl group, an aryl group, a substituted aryl group, a heteroaryl group, and a substituted heteroaryl group.
6 more elements
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A compound or a salt thereof, the compound comprising:
- a poly(amidoamine) dendrimer;
- and
- a plurality of substituents bound to amino groups of the poly(amidoamine) dendrimer, wherein each substituent independently has a formula (I):
- —X—(CH2)n—Z (I),
- wherein:
- X is a bond or —C(O)—O—;
- n is 0, 1 or 2;
- and
- Z is selected from a haloalkyl group, an aryl group, a substituted aryl, a heteroaryl group, and a substituted heteroaryl group.
6 more elements
17-27. (canceled)
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-36. (canceled)
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Dependencies are inferred from the claim text.