Detection of microbial endotoxins in oral samples using aptamers
AssigneeThe Procter & Gamble Company
InventorsSancai Xie, Thomas Glenn Huggins, JR., Cheryl Sue Tansky, Ping Hu, Susan Ellen Forest
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Abstract
The present invention is directed to an aptamer composition comprising at least one oligonucleotide consisting of: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, and mixtures thereof; wherein said aptamer composition has a binding affinity for one or more bacterial species from the genera Prevotella and Porphyromonas.
Claims30
An aptamer composition comprising an oligonucleotide that is at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof;
- wherein said aptamer composition has a binding affinity for one or more bacterial species from the genus Prevotella or the genus Porphyromonas.
A method for detecting endotoxins and outer membrane vesicles comprising:
- a) obtaining an oral cavity sample;
- b) applying an oral cavity sample to an assay kit;
- and
- c) measuring an assay result.
Dependencies are inferred from the claim text.