Dna-templated macrocycle library

A compound of Formula (I):

• or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, polymorph, tautomer, isotopically enriched form, or prodrug thereof,
• wherein:
• is a single or double C—C bond, wherein when is a double C—C bond, then indicates that the adjacent C—C double bond is in a cis or trans configuration;
• L1 is substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted carbocyclyene, substituted or unsubstituted arylene, or substituted or unsubstituted heterocyclylene;
• L2 is substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted carbocyclyene, substituted or unsubstituted arylene, or substituted or unsubstituted heterocyclylene;
• L3 is substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted carbocyclyene, substituted or unsubstituted arylene, or substituted or unsubstituted heterocyclylene;
• X is —O—C((R3A)(R3B))s—, —C((R3A)(R3B))s—, optionally substituted carbocyclylene, optionally substituted heterocyclylene, or optionally substituted arylene;
• R3A is hydrogen;
• halogen;
• substituted or unsubstituted aliphatic;
• substituted or unsubstituted heteroaliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• substituted or unsubstituted acyl;
• R3B is hydrogen;
• halogen;
• substituted or unsubstituted aliphatic;
• substituted or unsubstituted heteroaliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• substituted or unsubstituted acyl;
• or optionally R3A and R3B are joined together to form optionally substituted carbocyclyl or
• each instance of RE, RF, RG, RH, and RL is independently hydrogen;
• halogen;
• substituted or unsubstituted acyl;
• a nitrogen protecting group;
• substituted or unsubstituted aliphatic;
• substituted or unsubstituted heteroaliphatic;
• substituted or unsubstituted aryl;
• substituted or unsubstituted heteroaryl;
• substituted or unsubstituted hydroxyl;
• substituted or unsubstituted thiol;
• substituted or unsubstituted amino;
• or optionally RG and one instance of R3A or R3B are joined together with the intervening atoms to form optionally substituted heterocyclyl;
• m1 is 0, 1, or 2;
• s is 0, 1, 2, 3, or 4;
• and
• y is 0 or 1.