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US 2020/0399621 A1Published application
Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, Benjamin Kleinstiver
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Abstract
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
Claims30
An isolated Streptococcus pyogenes Cas9 (SpCas9) protein, with mutations at one or more of the following positions:
- G1104, S1109, L1111, D1135, S1136, G1218, N1317, R1335, T1337.
Dependencies are inferred from the claim text.