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US 2020/0399620 A1Published application
Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, Benjamin Kleinstiver
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Abstract
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
Claims30
An isolated Staphylococcus aureus Cas9 (SaCas9) protein with mutations at one or more of the following positions:
- E735, E782, K929, N968, A1021, K1044 and/or R1015.
Dependencies are inferred from the claim text.