Brown fat cells and method for preparing same

A method for generating a brown adipocyte from a somatic cell in a mammal, the method comprising introducing a polynucleotide encoding at least one brown adipocyte-related gene and a polynucleotide encoding at least one reprogramming-related gene into the somatic cell in the mammal, thereby expressing a brown adipocyte-related gene and a reprogramming-related gene in the somatic cell,

• wherein
• a combination of the at least one brown adipocyte-related gene and the at least one reprogramming-related gene is any combination selected from the group consisting of CM, PCLMG, CLMG, PCIM, CLM, PCMG, PCM, CL, and CMG, wherein P represents PRDM16, C represents C/EBP3, L represents L-Myc, M represents c-Myc, N represents N-Myc, and G represents Glis1,
• the polynucleotide encoding at least one brown adipocyte-related gene and the polynucleotide encoding at least one reprogramming-related gene are introduced into the somatic cell by infection with a viral vector, by transfection with a plasmid vector, or by transfection with an episomal vector,
• the brown adipocyte is directly induced from the somatic cell without first becoming an induced pluripotent stem (iPS) cell or an embryonic stem (ES) cell, and
• the somatic cell is a fibroblast or a white adipocyte.