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US 2020/0399597 A1Published application
T-cell receptor-deficient t cell compositions
AssigneeTrustees of Dartmouth College
InventorCharles L. SENTMAN
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AssigneeTrustees of Dartmouth College
InventorCharles L. SENTMAN
Estimating the term…
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
An isolated TCR-deficient T cell.
An isolated TCR-deficient T cell, wherein said T cell expresses at least one functional non-TCR receptor and does not express a functional TCR.
A T cell bank comprising TCR-deficient T cells of different tissue HLA types, wherein said T cell bank comprises different T cell containing compositions each composition containing T cells of a specific HLA type, which are TCR-deficient.
Dependencies are inferred from the claim text.