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US 2020/0399594 A1Published application
Morphogenic compound-releasing microspheres and use in bioink
AssigneeUVic Industry Partnerships Inc.
InventorsAndrew Agbay, Laura De La Vega, Stephanie Michelle Willerth
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Abstract
The bioink disclosed herein includes one or more cells, a carrier material, and microspheres. The microspheres can include one or more biodegradable polymers and one or more compounds, such as a morphogenic compound. The methods disclosed herein can include three-dimensional bioprinting. Additional methods disclosed herein include producing functional tissue.
Claims25
A bioink, comprising:
- one or more cells;
- a carrier material;
- and
- discrete microspheres, the discrete microspheres comprising:
- one or more biodegradable polymers;
- and
- one or more compounds,
- wherein the one or more compounds release with degradation of the one or more biodegradable polymers.
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A method of bioprinting, comprising:
- contacting at least one cell type with a microsphere solution and a bioink solution, producing a bioink-cell-microsphere composition;
- contacting the bioink-cell composition with a crosslinker, producing a crosslinked bioink-cell composition;
- and
- bioprinting at least one layer of the crosslinked bioink-cell composition using a bioprinter.
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Dependencies are inferred from the claim text.