Protein engineered extracellular vesicles
OwnerJustin HEAN, Per LUNDIN +1inventors
InventorsJustin HEAN, Per LUNDIN, Andre GORGENS
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Abstract
The present invention relates to extracellular vesicles (EVs) as a novel therapeutic approach to lysosomal storage disorders (LSD). More specifically, the invention relates to the use of various protein engineering strategies for improving loading of hard-to-load LSD-related proteins and targeting of the resultant EVs to tissues and organs of interest.
Claims27
Extracellular vesicles (EVs) obtainable from mesenchymal stromal cells (MSCs), amnion epithelial (AE) cells or placenta-derived cells, wherein the EVs comprise a plurality of polypeptide constructs comprising at least one lysosomal protein.
An EV-producing MSC, AE or placenta-derived cell comprising at least one polypeptide construct comprising at least one lysosomal protein, at least one polynucleotide construct encoding at least one lysosomal protein, and/or at least one vector comprising a polynucleotide construct encoding at least one lysosomal protein.
Dependencies are inferred from the claim text.