Covalently Cross-Linked Hyaluronic Acid Aerogel, Hydrogel, and Preparation Method Thereof

2:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the crosslinking agent is a diglycidyl ether crosslinking agent.

3:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the diglycidyl ether crosslinking agent is 1,4-butanediol diglycidyl ether, ethylene glycol diglycidyl ether or poly ethylene glycol diglycidyl ether (n=10, molecular weight:
• 500).

4:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the concentration of the crosslinking agent is 0.1% to 1% (v/v).

5:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the crosslinking reaction system reacts under a neutral condition of pH 6 to 8, preferably about 7.

6:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the molecular weight of hyaluronic acid is 3.5×105 to 1.5×106 Da.

7:

• The preparation method of a covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof according to claim 1, wherein the concentration of the hyaluronic acid aqueous solution is 0.5% to 4% (w/v).

8:

• A covalently cross-linked hyaluronic acid aerogel and a hydrogel thereof prepared by the method according to claim 1.

9:

• A use of the covalently cross-linked hyaluronic acid aerogel and the hydrogel thereof according to claim 7 in cell engineering, tissue engineering, drug carriers or cosmetic surgery.

10:

• The use according to claim 9, wherein as surgical sealant and adhesive or wound dressing to promote wound healing.