A method for treatment of a subject suffering from eye or retinal or neurodegenerative diseases, neural/neuronal eye or retinal diseases, geographic atrophy, age-related macular degeneration, diabetic retinopathy, diabetic macular edema, retinitis pigmentosa, inherited retinal dystrophy, inherited macular dystrophy, myopic degeneration, retinal vein occlusions, retinal artery occlusions, endophthalmitis, uveitis, cystoid macular edema, choroidal neovascular membrane secondary to any retinal diseases, optic neuropathies, glaucoma, retinal detachment, toxic retinopathy, radiation retinopathy, and traumatic retinopathy, prodromal and mild-to-moderate alzheimer's diseases, delaying disease progression of patients with Alzheimer's disease, Huntington's disease, Parkinson's disease, major depressive disorder, schizophrenia, cognitive impairment associated with schizophrenia, prevention of first-episode psychosis in individuals with attenuated psychosis syndrome, prevention of relapse in patients with schizophrenia, treatment-resistant depression, hyperphagia, obesity or metabolic syndrome, comprising administering to the subject a therapeutically effective amount of an anti-TrkB antibody or the antigen-binding fragment thereof comprising:
- I.a. a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 48 (L-CDR1);
- the amino acid sequence of SEQ ID NO:
- 49 (L-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 50 (L-CDR3);
- and
- I.b. a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 51 (H-CDR1);
- the amino acid sequence of SEQ ID NO:
- 52 (H-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 53 (H-CDR3), or
- I.c. a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 55 (H-CDR1);
- the amino acid sequence of SEQ ID NO:
- 56 (H-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 57 (H-CDR3), or
- I.d. a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 58 (H-CDR1);
- the amino acid sequence of SEQ ID NO:
- 59 (H-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 60 (H-CDR3), or
- II.a. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 2 and SEQ ID NO:
- 12, respectively, or
- II.b. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 3 and SEQ ID NO:
- 13, respectively, or
- II.c. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 4 and SEQ ID NO:
- 14, respectively, or
- II.d. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 5 and SEQ ID NO:
- 15, respectively, or
- II.e. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 6 and SEQ ID NO:
- 16, respectively, or
- II.f. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 7 and SEQ ID NO:
- 17, respectively, or
- II.g. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 8 and SEQ ID NO:
- 18, respectively, or
- II.h. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 9 and SEQ ID NO:
- 19, respectively, or
- II.i. a variable light chain and a variable heavy chain comprising the amino acid sequences of SEQ ID NO:
- 10 and SEQ ID NO:
- 20, respectively, or
- III.a. a light chain comprising the amino acid sequence of SEQ ID NO:
- 21 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 22 or 23, or
- III.b. a light chain comprising the amino acid sequence of SEQ ID NO:
- 24 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 25 or 26, or
- III.c. a light chain comprising the amino acid sequence of SEQ ID NO:
- 27 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 28 or 29, or
- III.d. a light chain comprising the amino acid sequence of SEQ ID NO:
- 30 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 31 or 32, or
- III.e. a light chain comprising the amino acid sequence of SEQ ID NO:
- 33 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 34 or 35, or
- III.f. a light chain comprising the amino acid sequence of SEQ ID NO:
- 36 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 37 or 38, or
- III.g. a light chain comprising the amino acid sequence of SEQ ID NO:
- 39 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 40 or 41, or
- III.h. a light chain comprising the amino acid sequence of SEQ ID NO:
- 42 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 43 or 44, or
- III.i. a light chain comprising the amino acid sequence of SEQ ID NO:
- 45 and a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 46 or 47.