Anti-cd47 antibodies and uses thereof
AssigneeLepu Biopharma Co., Ltd.
InventorsWenci Gong, Zhaokun Meng, Yiwei Tou
Life of this patent
Estimating the term…
Abstract
Provided are anti-CD47 antibodies and fragments thereof. The antibodies and fragments thereof specifically bind to the CD47 protein. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and atherosclerosis are also provided.
Claims25
An antibody or fragment thereof, wherein the antibody or fragment thereof has specificity to a human CD47 (Cluster of Differentiation 47) protein and comprises:
- (a) a VH CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) a VH CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 7;
- (c) a VH CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3 or SEQ ID NO:
- 8;
- (d) a VL CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4 or SEQ ID NO:
- 9;
- (e) a VL CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and
- (f) a VL CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6 or SEQ ID NO:
- 10.
(canceled)
(canceled)
The antibody or fragment thereof of claim, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:18 or 19, and the light chain variable region comprises the amino acid sequence of SEQ ID NO:20.
19-20. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.