Anti-claudin 18.2 antibodies and uses thereof

An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequences of:

• a. SEQ ID NOs:
• 33, 34, 35, 63, 64 and 65, respectively, or SEQ ID NOs:
• 93, 94, 95, 123, 124 and 125, respectively;
• b. SEQ ID NOs:
• 21, 22, 23, 51, 52 and 53, respectively, or SEQ ID NOs:
• 81, 82, 83, 111, 112 and 113, respectively;
• c. SEQ ID NOs:
• 24, 25, 26, 54, 55 and 56, respectively, or SEQ ID NOs:
• 84, 85, 86, 114, 115 and 116, respectively;
• d. SEQ ID NOs:
• 27, 28, 29, 57, 58 and 59, respectively, or SEQ ID NOs:
• 87, 88, 89, 117, 118 and 119, respectively;
• e. SEQ ID NOs:
• 30, 31, 32, 60, 61 and 62, respectively, or SEQ ID NOs:
• 90, 91, 92, 120, 121 and 122, respectively;
• f. SEQ ID NOs:
• 36, 37, 38, 66, 67 and 68, respectively, or SEQ ID NOs:
• 96, 97, 98, 126, 127 and 128, respectively;
• g. SEQ ID NOs:
• 39, 40, 41, 69, 70 and 71, respectively, or SEQ ID NOs:
• 99, 100, 101, 129, 130 and 131, respectively;
• h. SEQ ID NOs:
• 42, 43, 44, 72, 73 and 74, respectively, or SEQ ID NOs:
• 102, 103, 104, 132, 133 and 134, respectively;
• i. SEQ ID NOs:
• 45, 46, 47, 75, 76 and 77, respectively, or SEQ ID NOs:
• 105, 106, 107, 135, 136 and 137, respectively;
• or
• j. SEQ ID NOs:
• 48, 49, 50, 78, 79 and 80, respectively, or SEQ ID NOs:
• 108, 109, 110, 138, 139 and 140, respectively;
• wherein the antibody or antigen-binding fragment thereof specifically binds claudin 18.2 (CLDN18.2).