Therapy for glaucoma and optic neuropathy by targeting colony stimulating factors
AssigneeThe Schepens Eye Research Institute, Inc.
InventorsJi Min, Kin-Sang Cho, Dong Feng Chen
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Abstract
The invention provides compositions and methods for treating optic neuropathic disorders.
Claims27
A method for treating an optic neuropathic disorder in a subject comprising locally administering to the eye an inhibitor of colony stimulating factor-1 (CSF1) or a receptor thereof or by locally administering to the eye a colony stimulating factor-2 (CSF2) protein or polypeptide.
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A method of preventing or treating an optic neuropathic disorder or a method of suppressing or inhibiting microglial in a subject comprising locally administering to the eye, a pharmaceutical composition comprising a therapeutically effective amount of an inhibitor of colony stimulating factor-1 (CSF1) or a receptor thereof and a colony stimulating factor-2 (CSF2) polypeptide, thereby preventing or treating the optic neuropathic disorder.
A pharmaceutical composition comprising a therapeutically effective amount of an inhibitor of colony stimulating factor-1 (CSF1) or a receptor thereof and a colony stimulating factor-2 (CSF2) protein or polypeptide.
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Dependencies are inferred from the claim text.