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US 2020/0399350 A1Published application
Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
AssigneeJanssen Vaccines & Prevention B.V.
InventorsJehangir WADIA, Gabriel PASCUAL, Robert Anthony WILLIAMS, Katarina RADOSEVIC, Jaap GOUDSMIT
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Abstract
The invention relates to antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using anti-tau antibodies.
Claims17
A monoclonal antibody, wherein the antibody binds tau deposits in human AD brain tissue,
- wherein the antibody binds tau deposits in human AD brain tissue, but does not bind tau in normal human brain tissue and does not bind tau deposits in Progressive Supranuclear Palsy (“PSP”) brain tissue;
- and
- wherein the antibody comprises an antigen-binding site of a VH of SEQ ID NO:87 and an antigen-binding site of a VL of SEQ ID NO:88.
Dependencies are inferred from the claim text.