Nk cell-directed chimeric proteins
AssigneeShattuck Labs, Inc.
InventorsTaylor SCHREIBER, Casey SHUPTRINE, George FROMM, Suresh DE SILVA
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Abstract
The present invention relates, inter alia, to compositions and methods, including chimeric proteins comprising an extracellular domain of a Type I transmembrane protein or a portion of a membrane-anchored extracellular protein and a portion of the extracellular domain of a Type II transmembrane protein, wherein the Type II transmembrane protein is naturally expressed on the surface of a Natural Killer (NK) cell that find use in the treatment of disease, such as cancer and viral infections.
Claims28
-93. (canceled)
A chimeric protein of a general structure of:
- N terminus-(a)-(b)-(c)-C terminus,
- wherein:
- (a) is a first domain comprising an extracellular domain of CD86, the first domain capable of binding a CD86 ligand/receptor,
- (b) is a linker, and
- (c) is a second domain comprising an extracellular domain of NKG2A, the second domain capable of binding an NKG2A ligand/receptor,
- wherein the linker connects the first domain and the second domain.
A chimeric protein comprising:
- (a) a first domain comprising a portion of CD86 comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 63,
- (b) a second domain comprising a portion of NKG2A comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 57, and
- (c) a linker linking the first domain and the second domain and comprising a hinge-CH2-CH3 Fc domain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 2, or SEQ ID NO:
- 3, and optionally further comprising one, two, or more joining linkers independently selected from SEQ ID NOs:
- 4-50.
Dependencies are inferred from the claim text.