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US 2020/0399342 A1Published application
Tigit- and light-based chimeric proteins
AssigneeShattuck Labs, Inc.
InventorsTaylor SCHREIBER, George FROMM, Suresh DE SILVA
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Abstract
The present invention relates, inter alia, to compositions and methods, including TIGIT- and/or LIGHT-based chimeric proteins that find use in the treatment of disease, such as cancer and an inflammatory disease.
Claims27
-47. (canceled)
A chimeric protein of a general structure of:
- N terminus-(a)-(b)-(c)-C terminus,
- wherein:
- (a) is a first domain comprising an extracellular domain of TIGIT,
- (b) is a linker comprising at least one cysteine residue capable of forming a disulfide bond, and
- (c) is a second domain comprising an extracellular domain of LIGHT,
- wherein the linker connects the first domain and the second domain.
3 more elements
Dependencies are inferred from the claim text.