Novel growth hormone receptor antagonist and fusion protein thereof
AssigneeAlteogen, Inc.
InventorsSoon Jae PARK, Jaehyeong KO, Sun-Ah YOU, Sang Hoon YUN
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Abstract
The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.
Claims18
A growth hormone receptor antagonist comprising a growth hormone variant in which one or more amino acids in an amino acid sequence of growth hormone are substituted with another amino acid.
A method of preparing a growth hormone receptor antagonist, the method comprising the step of culturing cells comprising a polynucleotide encoding the growth hormone variant in which one or more amino acids in an amino acid sequence of growth hormone are substituted with another amino acid.
Dependencies are inferred from the claim text.