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US 2020/0399335 A1Published application
Modified immunomodulatory peptide
AssigneeAarhus Universitet
InventorsMartin Roelsgaard Jakobsen, Claus Elsborg Olesen
Life of this patent
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Abstract
Modified polypeptides derived from the pyrin-domain of IFI16 are provided as well as their uses in medicine. Specifically, the polypeptides are provided for use in the treatment of disorders associated with STING activity, including cancer and immunodeficient or auto-immune disorders.
Claims28
1-33. (canceled)
A polypeptide or polypeptide analog, wherein the polypeptide or polypeptide analog comprises an amino acid sequence of the general formula:
- KKX3KNIVLLX10GLX13VINX17YHF (SEQ ID NO:
- 31)
- wherein X is selected from any proteinogenic and non-proteinogenic amino acid residues, with the proviso that one or more of X3 is not tyrosine (Y), X10 is not lysine (K), X13 is not glutamic acid (E) and X17 is not aspartic acid (D).
Dependencies are inferred from the claim text.