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US 2020/0399332 A1Published application
Variant aim
AssigneeToro Miyazaki
InventorsToru Miyazaki, Satoko Arai
Life of this patent
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Abstract
The present invention relates to the provision of a recombinant AIM that maintains functions, does not multimerize, and is not inactivated by IgM (e.g., a protein containing an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and the like).
Claims16
A mutant human AIM comprising an amino acid sequence of any one of the following (1) to (5) and having an activity of wild-type human AIM:
- (1) an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO:
- 1 is substituted with another amino acid,
- (2) an amino acid sequence wherein cysteine at amino acid number 277 of the amino acid sequence shown in SEQ ID NO:
- 1 is substituted with another amino acid,
- (3) an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO:
- 1 is substituted with another amino acid, and an amino acid sequence wherein cysteine at amino acid number 277 of the amino acid sequence shown in SEQ ID NO:
- 1 is substituted with another amino acid,
- (4) an amino acid sequence substantially the same as the amino acid sequence of any one of (1) to (3), and cysteines present in the amino acid sequence of any one of (1) to (3) and the substituted another amino acid remain, or
- (5) an amino acid sequence further comprising deletion, addition, insertion or substitution of one to several amino acids or a combination thereof at a position other than cysteines present in the amino acid sequence of any one of (1) to (3) and the substituted another amino acid.
6 more elements
A mutant mouse AIM comprising an amino acid sequence of any one of the following (1) to (3) and having an activity of wild-type mouse AIM:
- (1) an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO:
- 2 is substituted with another amino acid,
- (2) an amino acid sequence substantially the same as the amino acid sequence of (1), and cysteines present in the amino acid sequence of (1) and the substituted another amino acid remain, or
- (3) an amino acid sequence further comprising deletion, addition, insertion or substitution of one to several amino acids or a combination thereof at a position other than cysteines present in the amino acid sequence of (1) and the substituted another amino acid.
1 more element
Dependencies are inferred from the claim text.