Recombinant adenoviruses and uses thereof
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsDan H. BAROUCH, Peter ABBINK, Mark Justin IAMPIETRO, Menzo J. E. HAVENGA
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Abstract
Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
Claims172
An isolated polynucleotide or complement thereof comprising a nucleotide sequence encoding a hexon protein, wherein the nucleotide sequence encoding the hexon protein has at least 93% sequence identity over the entire sequence of any one of SEQ ID NOs:
- 55, 58, 59, 61, 62, 64, 65, and 67.
An isolated polynucleotide or complement thereof comprising a nucleotide sequence encoding a hexon protein, wherein the nucleotide sequence encoding the hexon protein has 99% or greater sequence identity over the entire nucleic acid sequence of SEQ ID NO:
- 56.
An isolated polynucleotide or complement thereof comprising a nucleotide sequence encoding three adenoviral fiber proteins.
Dependencies are inferred from the claim text.