Back to results
US 2020/0399320 A1Published application
Chimeric Polypeptides and Uses Thereof
AssigneeKite Pharma, Inc.
InventorsJed J.W. WILTZIUS, Stuart A. SIEVERS
Life of this patent
Estimating the term…
Abstract
The invention provides novel peptides (e.g., linkers) and polypeptide compositions comprising the linkers (e.g., fusion proteins) and methods of using the polypeptide compositions. Peptides (e.g., linkers) are useful as tags and for engineering fusion proteins (e.g., antigen binding molecules, scFv). Polypeptide linkers described herein facilitate flexibility of linked peptides allowing for proper folding, conformation and reduced immunogenicity.
Claims12
1-14. (canceled)
A fusion protein comprising:
- a first polypeptide and a second polypeptide covalently linked by
- a peptide comprising a consensus sequence GKPGSGZ,
- wherein the peptide is 6-20 amino acids in length;
- wherein Z is glycine (G) or a negatively charged amino acid;
- and
- wherein the peptide is not GSTSGSGKPGSGEGSTKG (SEQ ID NO:
- 1), GSGKPGSGEG (SEQ ID NO:
- 13), GKPGSGEG (SEQ ID NO:
- 14), or SGKPGSGE (SEQ ID NO:
- 15).
7 more elements
Dependencies are inferred from the claim text.