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US 2020/0399314 A1Published application
Il-2alpha receptor subunit binding compounds
AssigneeMedikine, Inc.
InventorsWILLIAM J. DOWER, MICHAEL C. NEEDELS, RONALD W. BARRETT, ALICE V. BAKKER, STEVEN E. CWIRLA
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Abstract
Peptidyl IL-2Rα ligands and compounds comprising the IL-2Rα ligands are disclosed. The IL-2Rα ligands and compounds such as synthetic monomers, homodimers, or heteromers and recombinant fusion proteins comprising the IL-2Rα ligands can be used as targeting or imaging agents, as diagnostics or to treat cancers and autoimmune diseases.
Claims28
An IL-2Rα ligand, wherein,
- the IL-2Rα ligand bind to the human IL-2Rα subunit with an IC50 of less than 100 μM;
- and
- the IL-2Rα ligand comprises an amino acid sequence selected from any one of SEQ ID NOS:
- 4, 9, 24, 31, 44, 50, 67, 79, 100, 112, 135, 144, 154, 172, 180, 203, 210, 219, 234, 250, and 418:
- SEQ ID NO:
- 4
- F L H W P V Y F C Q V M
- SEQ ID NO:
- 9
- F I P W D E Y F K Q V L
- SEQ ID NO:
- 24
- F V H C T L L G C W S G
- SEQ ID NO:
- 31
- W V I C S A V G C R P F
- SEQ ID NO:
- 44
- H V I C S V N G G C R G
- SEQ ID NO:
- 50
- E Q F C L V S D P M A C W S L
- SEQ ID NO:
- 67
- R R F C L R S E P A A C W F V
- SEQ ID NO:
- 79
- S K C V Y D Y N F G T C I F
- SEQ ID NO:
- 100
- S L N C K T R P G L R W C T W T
- SEQ ID NO:
- 112
- A W E C L F L P G H R G C S L F
- SEQ ID NO:
- 135
- R Q F C L V S P G Y E D C W F V
- SEQ ID NO:
- 144
- S A C Q L K W D E G W T C L F
- SEQ ID NO:
- 154
- R G C S L V W S G S W E C I F
- SEQ ID NO:
- 172
- G C T L S W N Q G W W H C V
- SEQ ID NO:
- 180
- A R C S L H H T G S R Y E C I F
- SEQ ID NO:
- 203
- T C R L K R S G P N S W E C I
- SEQ ID NO:
- 210
- V R C R L A R P G L T W E C L S
- SEQ ID NO:
- 219
- Q L C P W S D P G S W G P C P L
- SEQ ID NO:
- 234
- G C Q L V W Q D D S Y M C F Y
- SEQ ID NO:
- 250
- W C I G Q P L F R Q G S C K
- SEQ ID NO:
- 418
- F V P W D V Y F S Q I L G G
64 more elements
Dependencies are inferred from the claim text.